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Dexamethasone, 96%, Thermo Scientific Chemicals
Dexamethasone, CAS# 50-02-2, is a synthetic adrenal corticosteroid that shows potent anti-inflammatory activity.
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Catalog number FSA230302500
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Quantity:
250 mg
Packaging:
Glass bottle
Specifications
Chemical Name or MaterialDexamethasone
CAS50-02-2
Health Hazard 1GHS Signal Word: Warning
Health Hazard 2GHS H Statement:
Suspected of causing cancer.
Suspected of causing cancer.
Health Hazard 3GHS P Statement:
Use personal protective equipment as required.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
Use personal protective equipment as required.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Dexamethasone is a synthetic adrenal glucocorticoid that modulates carbohydrate metabolism, inhibits adrenocorticotropic hormone secretion, and has pronounced anti-inflammatory activity
• Dexamethasone can bind to specific nuclear steroid receptors, inhibiting pro-inflammatory signals, promoting anti-inflammatory signals, and interfering with NF-kB activation and apoptotic pathways
Applications
• It can be used to study apoptosis, cell signaling pathways, and gene expression
• This compound also shows adrenergic, antiemetic, and antineoplastic activities
• It has been used as an important regulator of cellular proliferation and differentiation in vitro human cell cultures
• Dexamethasone has been applied in culture media to promote the differentiation of adipose-derived stem cells into osteogenic tissue
• It is used in in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)
• This compound is used for its ability to regulate T cell survival, growth, and differentiation.
• It can also inhibit the induction of nitric oxide synthase.
RUO – Research Use Only
General References:
- McCulloch, C.; Tenenbaum, H. Dexamethasone induces proliferation and terminal differentiation of osteogenic cells in tissue culture. Anat Rec. 1986, 215, (4), 397-402.
- Pasarica, M.; Mashtalir, N.; McAllister, E. et al.Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells. Stem Cells. 2008, 26, (4), 969-978.
- Han, L.; Wang, Z.; Lu, X.; Dong, L.; Xie, C.; Wang, K.; Chen, X.; Ding, Y.; Weng, L. Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate. Colloids Surf., B 2015, 126, 452-458.
- Khataee, A.; Hasanzadeh, A.; Lotfi, R.; Pourata, R.; Joo, S. W. Determination of dexamethasone by flow-injection chemiluminescence method using capped CdS quantum dots. Spectrochim. Acta, Part A 2015, 150 (5), 63-71.