Cefsulodin sodium salt hydrate, 97%

Cefsulodin sodium (sulcephalosporin, CAS # 52152-93-9) is the salt of the semi-synthetic cephalosporin antibiotic. | CAS: 1426397-23-0 | C22H21N4NaO8S2+ | 556.54 g/mol

Catalog Number	Quantity
ALFJ66120.03	1 g

Catalog number ALFJ66120.03

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Specifications

Chemical Name or MaterialCefsulodin sodium salt hydrate

TypeCefsulodin Sodium Salt

Physical FormPowder

CAS1426397-23-0

Health Hazard 1H315-H317-H319-H334-H335

Cefsulodin is most commonly used in CIN agar to select for Yersinia microorganisms. The compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-resistant mutants of Pseudomonas aeruginosa PAO4089 growth displayed that Cefsulodin sodium salt hydrate may compete with PBP3 in addition to PBP1A and PBP1B.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cefsulodin sodium is a third-generation cephalosporin antibiotic with a narrow range of effectiveness
• Cefsulodin competitively inhibits penicillin binding protein, preventing cell wall synthesis and promoting lysis

Application

• Cefsulodin is mainly effective against Yersinia microorganisms, Pseudomonas aeruginosa, and Staphylococcus aureus
• Cefsulodin is useful for drug resistance studies involving susceptible microbes and for studies related to drug mechanisms
• It is appropriate for selection experiments and other cell culture applications

RUO – Research Use Only

General References:

Bakthavatsalam D, Craft JW Jr, Kazansky A, Nguyen N, Bae G, Caivano AR, Gundlach CW 4th, Aslam A, Ali S, Gupta S, Lin SY, Parthiban HD, Vanderslice P, Stephan CC, Woodside DG. Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk. Front Immunol. 2021 Jan 8;11:575085. doi: 10.3389/fimmu.2020.575085. PMID: 33488575; PMCID: PMC7819857.
Pazos M, Peters K, Boes A, Safaei Y, Kenward C, Caveney NA, Laguri C, Breukink E, Strynadka NCJ, Simorre JP, Terrak M, Vollmer W. SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli. mBio. 2020 Nov 3;11(6):e02796-20. doi: 10.1128/mBio.02796-20. PMID: 33144379; PMCID: PMC7642682.