Hygromycin B

Name: Hygromycin B
SKU: ALFJ60681.MD

Hygromycin B, CAS # 31282-04-9, is an aminoglycoside compound showing antibiotic activity that kills bacteria through the inhibition of protein synthesis. It also presents anthelmintic activity. | CAS: 31282-04-9 | C20H37N3O13 | 527.524 g/mol

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Catalog number ALFJ60681.MD

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Specifications

Chemical Name or MaterialHygromycin B

TypeHygromycin B

Physical FormLyophilized Powder

CAS31282-04-9

Health Hazard 1H300+H310+H330-H317-H318-H334

An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
Hygromycin also presents an anthelmintic activity against nematode parasites of chickens

RUO – Research Use Only

General References:

Chen, C. F.; Chan, K. G.; Tan, B. C.; Khalid, N. Enhancement of Agrobacterium-mediated transformation efficiency of model plant using quorum sensing molecule, N-3-oxo-octanoyl-l-homoserine-lactone. Plant Cell Tissue Organ Cult. 2015, 121 (2), 481-487.
Park, Y.; Hosomichi, J.; Ge, C.; Xu, J.; Franceschi, R.; Kapila, S. Immortalization and characterization of mouse temporomandibular joint disc cell clones with capacity for multi-lineage differentiation. Osteoarthr. Cartil. 2015, 23 (9), 1532-1542.