Doxycycline hydrochloride
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Doxycycline hydrochloride
Doxycycline hydrochloride
Doxycycline hydrochloride
Thermo Scientific Chemicals

Doxycycline hydrochloride

Doxycycline hydrochloride, CAS # 10592-13-9, is the hydrochloride salt form of doxycycline that shows antibacterial and antimalarial activities. | CAS: 10592-13-9 | C22H25ClN2O8 | 480.90 g/mol
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Catalog NumberQuantity
ALFJ60422.1425 g
Catalog number ALFJ60422.14
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Quantity:
25 g
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Specifications
Chemical Name or MaterialDoxycycline hydrochloride
TypeDoxycycline Hydrochloride
Physical FormCrystalline Powder
CAS10592-13-9
Health Hazard 1H302+H312+H332-H315-H319-H335
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Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinases.Doxycycline hydrochloride is an antibiotic used to inhibit matrix metalloproteinases like type 1 collagenase in studies on would healing and tissue remodeling. It shows the broad spectrum antibacterial and antiprotozoan activity. It is often used to treat lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Doxycycline hydrochloride is a compound that shows antibacterial and antimicrobial activities against several species, including Pseudomonas aeruginosa, Plasmodium falciparum, and Escherichia coli. It is also a bacteriostatic
  • It can block the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis

Application

  • It is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and eliminate Ixodes scapularis ticks
  • Doxycycline hydrochloride is also considered to be a broad-spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase, in wound healing and tissue remodeling studies. Due to this activity, it can inhibit angiogenesis and reduce lung metastases
RUO – Research Use Only

General References:

  1. Z Qiang.; C Adams. Potentiometric determination of acid dissociation constants (pK a) for human and veterinary antibiotics. Water research. 2004, 38, (12), 2874-2890.
  2. JB Bogardus.; RK Blackwood. Solubility of doxycycline in aqueous solution. Journal of Pharmaceutical Sciences. 1979, 68, (2), 188-194.