Bafilomycin A1, 95%
Element SearchElement SearchStructure SearchStructure Search
Bafilomycin A1, 95%
Bafilomycin A1, 95%
Bafilomycin A1, 95%
Thermo Scientific Chemicals

Bafilomycin A1, 95%

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol
Have Questions?
Catalog NumberQuantity
ACR3281200010.1 mg
Catalog number ACR328120001
View Price:Sign in to see your account pricing. Need an account? Register with us today.
Quantity:
0.1 mg
Request bulk or custom format
Specifications
Chemical Name or MaterialBafilomycin A1
TypeBafilomycin A1
Name Note95%
Physical FormPowder/Solid
CAS88899-55-2
View more
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
  • It is a macrolide antibiotic, and shows fungicide activity

Application

  • Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
  • It can be immunosuppressive
  • It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
  • It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
RUO – Research Use Only

General References:

  1. Miao, Y.; Li, G.; Zhang, X.; Xu, H.; Abraham, S. N. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015, 161 (6), 1306-1319.
  2. Lee, K. I.; Kim, M. J.; Koh, H.; Lee, J. I.; Namkoong, S.; Oh, W. K.; Park, J.The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. Biochem. Biophys. Res. Commun. 2015, 462 (4), 402-408.