Gabapentin, 98%
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Gabapentin, 98%
Gabapentin, 98%
Gabapentin, 98%
Thermo Scientific Chemicals

Gabapentin, 98%

Gabapentin, CAS # 60142-96-3, is a synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant and analgesic activities. | CAS: 60142-96-3 | C9H17NO2 | 171.24 g/mol
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Catalog number FSA458020250
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Specifications
Chemical Name or MaterialGabapentin
Melting Point166.0°C
CAS60142-96-3
Health Hazard 1GHS Signal Word: Danger
Health Hazard 2GHS H Statement
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
May damage the unborn child.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Gabapentin is a water-soluble GABA analog with anticonvulsant and analgesic activities
  • The exact mechanism of action is unknown but it has been described that this compound inhibits excitatory neuron activity by interacting with voltage-gated calcium channels in cortical neurons

Application

  • Gabapentin has been used as the α2δ-ligand to examine whether the allyl isothiocyanate (AITC) sensitized thermal aversion assay might be useful as a screening method for the identification of presumptive analgesics
RUO – Research Use Only

General References:

  1. Curtright, A.; Rosser, M.; Goh, S.; Keown, B.; Wagner, E.; Sharifi, J.; Raible, D.W.; Dhaka, A. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One. 2015, 14, 10, (1), e0116766.
  2. Yasaei, R.; Katta, S.; Saadabadi, A. Gabapentin. [Updated 2021 Dec 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.