Finasteride, 98%

Name: Finasteride, 98%
SKU: FSA458000010

Finasteride, CAS # 98319-26-7, is a 5α-reductase inhibitor that blocks conversion of testosterone and inhibits neurosteroid production.

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1 g

Catalog number FSA458000010

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Specifications

Chemical Name or MaterialFinasteride

CAS98319-26-7

Health Hazard 1GHS Signal Word: Danger

Health Hazard 2GHS H Statement
Harmful if swallowed.
May damage the unborn child.

Health Hazard 3GHS P Statement
Wash face,hands and any exposed skin thoroughly after handling.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
Obtain special instructions before use.
Use personal protective equipment as

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Finasteride is an inhibitor of the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT)
Finasteride also has been explored in neuroscience, as 5α-reductase enzymes are present in the central nervous system
Finasteride has been seen to cross the blood-brain barrier and block production of neurosteroids

Applications

Finasteride is mainly used in studies of prostate hyperplasia and tumors in mice, and can be studied in vitro or in vivo for its effects on hyperplasia, proliferation, and antioxidant activity
Its activity has also been explored in brain, liver and testis tissues
In vivo injection of finasteride has been shown to decrease neurogenesis and influence neuronal plasticity in mice

RUO – Research Use Only

General References:

Kim, H.J.; Kim, T.J.; Kim, Y.G.; Seong, C.; Cho, J.H.; Kim, W.; Lee, K.H.; Kim, D.Y. Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells. Pharmaceutics. 2021, 13(9), 1410.
Chhipa, R.R.; Halim, D.; Cheng, J.; Zhang, H.Y.; Mohler, J.L.; Ip, C.; Wu, Y. The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific. Prostate. 2013, 73(14), 1483-94.
Römer, B.; Pfeiffer, N.; Lewicka, S.; Ben-Abdallah, N.; Vogt, M.A.; Deuschle, M.; Vollmayr, B.; Gass, P. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Pharmacopsychiatry. 20100, 43(5), 174-8.