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Fluconazole, 98%
Fluconazole, 98%, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C13H12F2N6O | 306.27 g/mol
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Catalog number FSA455480050
Price (MYR)
1,491.00
EA
Quantity:
5 g
Price (MYR)
1,491.00
EA
Specifications
Chemical Name or MaterialFluconazole
CAS86386-73-4
Health Hazard 1GHS Signal Word: Warning
Health Hazard 2GHS H Statement
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May damage the unborn child.
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May damage the unborn child.
Health Hazard 3GHS P Statement
IF ON SKIN: Wash with plenty of soap and water.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses,if present and easy to do.
Continue rinsing.
IF INHALED: Remove to fresh air and kee
IF ON SKIN: Wash with plenty of soap and water.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses,if present and easy to do.
Continue rinsing.
IF INHALED: Remove to fresh air and kee
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
RUO – Research Use Only
General References:
- Clancy, C.J.; Yu, V.L.; Morris, A.J.; Snydman, D.R.; Nguyen, M.H. Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia. Antimicrob Agents Chemother. 2005, 49 (8), 3171-3177.
- Matsui, K.; Tsume, Y.; Amidon, G. E.; Amidon, G. L. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents. Mol. Pharmaceutics. 2015, 12 (7), 2418-2428.
- Bhardwaj, T.; Bhardwaj, V.; Sharma, K.; Gupta, A.; Cameotra, S. S.; Sharma, P. Thermo-acoustical analysis of sodium dodecyl sulfate: Fluconazole (antifungal drug) based micellar system in hydro-ethanol solutions for potential drug topical application. J. Chem. Thermodyn. 2014, 78, 1-6.