Tobramycin, 97%

Name: Tobramycin, 97%
SKU: FSA455430010

Tobramycin, CAS# 32986-56-4, is an aminoglycoside antibiotic isolated from Streptomyces tenebrarius with a wide range of bacteriostatic activity, mainly against gram-negative bacteria.

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Catalog number FSA455430010

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Specifications

Chemical Name or MaterialTobramycin

TypeTobramycin

CAS32986-56-4

Health Hazard 1Warning

Health Hazard 2GHS H Statement Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Tobramycin is an aminoglycoside compound derived from kanamycin B and displays antibiotic and bacteriostatic activity against gram-negative bacteria
• After entering the cells, it binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, consequently inhibiting the protein synthesis process leading to bacterial cell death
• Tobramycin also can interfere with protein elongation since it can induce misreading of the mRNA template, and cause incorrect amino acids to be incorporated into the growing polypeptide chain

RUO – Research Use Only

General References:

Meyer, R.; Young, L., Armstrong, D. Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa. Appl Microbiol. 1971, 22, (6), 1147-1151.
Coulter, L.; McLean, R.; Rohde, R.; Aron, G. Effect of bacteriophage infection in combination with tobramycin on the emergence of resistance in Escherichia coli and Pseudomonas aeruginosa biofilms. Viruses. 2014, 3, 6 (10), 3778-3786.
Vicens, Q.; Westhof, E. Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. Chemistry & biology. 2002, 9 (6), 747-755.