Cloxacillin sodium salt monohydrate

Name: Cloxacillin sodium salt monohydrate
SKU: FSA455300050

Cloxacillin sodium salt monohydrate, CAS # 7081-44-9, is a compound that targets gram-positive bacteria and shows antibacterial activity.

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Catalog number FSA455300050

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Specifications

Chemical Name or MaterialCloxacillin sodium salt monohydrate

TypeCloxacillin Sodium Salt Monohydrate

CAS7081-44-9

Health Hazard 1Danger

Health Hazard 2GHS H Statement Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cloxacillin sodium salt monohydrate is a chlorinated derivative of oxacillin that shows β-lactamase-resistant antibiotic activity

• This compound inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis, that is mediated by bacterial cell wall autolytic enzymes

Applications

• Cloxacillin sodium salt monohydrate targets gram-positive bacteria, and is effective against staphylococci that produce β-lactamase

• It acts in vitro against both penicillin gram-resistant and gram-sensitive staphylococci, certain streptococci, and pneumococci

• This compound is commonly used in vivo and in vitro studies as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics

RUO – Research Use Only

General References:

A New Antibacterial Agent: Sodium Cloxacillin Monohydrate (Tegopen). Journal of the American Medical Association. 1966, 195, 569-570.
Harris, P.N.; Ferguson, J.K. Antibiotic therapy for inducible AmpC β-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012, 40, (4), 297-305.