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General Information
• Ciprofloxacin is considered a synthetic broad-spectrum second-generation compound with antibiotic activity mainly against gram-negative bacteria
• It inhibits bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication, cell division, and causes double-strand breaks in the bacterial chromosome
Applications
• Ciprofloxacin presents more activity against gram-negative bacteria than gram-positive bacteria.
• Ciprofloxacin does not present cross-resistance between fluoroquinolones and other antibiotics classes, which is beneficial in laboratory experiments when other antibiotics are no longer effective
General References: