Tyramine hydrochloride, 99%

Name: Tyramine hydrochloride, 99%
SKU: FSA422380250

Tyramine hydrochloride, CAS # 60-19-5, is the hydrochloride salt of tyramine, a biogenic amine derived from the amino acid tyrosine. | CAS: 60-19-5 | C8H12ClNO | 173.64 g/mol

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Quantity:

25 g

Packaging:

Glass bottle

Catalog number FSA422380250

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Quantity:

25 g

Packaging:

Glass bottle

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Specifications

Chemical Name or MaterialTyramine hydrochloride

CAS60-19-5

Health Hazard 1GHS Signal Word: Warning

Health Hazard 2GHS H Statement
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Health Hazard 3GHS P Statement
Wear protective gloves/protective clothing/eye protection/face protection.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Tyramine is a naturally occurring monoamine that is derived from the decarboxylation of the amino acid tyrosine utilized in human and invertebrate nervous systems
Tyramine is synthesized and released from neurons and acts as a neuromodulator upon binding to tyramine receptors
Tyramine has been found to impact the immune system and cardiovascular system in humans

Applications

Tyramine may be used to form tyramide conjugate, which can be used as a signal amplification reagent in immunofluorescence assays
Tyramine-hyaluronic acid conjugates can be used to form biodegradable hydrogels, with utility in drug delivery and tissue engineering
Tyramine is useful for laboratory studies of neuronal stimulation

RUO – Research Use Only

General References:

Nagaya, Y.; Kutsukake, M.; Chigusa, S.I.; Komatsu, A. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Neurosci Lett. 2002, 329(3), 324-8.
Lange, A.B. Tyramine: from octopamine precursor to neuroactive chemical in insects. Gen Comp Endocrinol. 2009, 162(1), 18-26.
Kurisawa, M.; Chung, J.E.; Yang, Y.Y.; Gao, S.J.; Uyama, H. Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. Chem Commun (Camb). 2005, (34), 4312-4.
Klimovich, B.; Stiewe, T.; Timofeev, O. Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle. 2020, 19(1), 109-123.