4-Hydroxy-2-butanone, 95%
4-Hydroxy-2-butanone, 95%
4-Hydroxy-2-butanone, 95%
4-Hydroxy-2-butanone, 95%
Thermo Scientific Chemicals

4-Hydroxy-2-butanone, 95%

CAS: 590-90-9 | C4H8O2 | 88.106 g/mol
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100 g
25 g
Catalog number ALFL11456.22
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100 g
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Specifications
Chemical Name or Material4-Hydroxy-2-butanone
CAS590-90-9
Health Hazard 1H227-H315-H319-H335
Health Hazard 2GHS H Statement
H315-H319-H335-H227
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Combustible liquid.
Health Hazard 3P210-P235-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P370+P378q-P501c
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4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones.

Solubility
Miscible with water, alcohol, ethanol and ether.

Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Mei, J.; Mao, J.; Chen, Z.; Yuan, S.; Li, H.; Yin, H. Mechanism and kinetics of 4-hydroxy-2-butanone formation from formaldehyde and acetone under supercritical conditions and in high-temperature liquid-phase. Chem. Eng. Sci. 2015, 131, 213-218.
  2. Bouzidi, H.; Aslan, L.; El Dib, G.; Coddeville, P.; Fittschen, C.; Tomas, A. Investigation of the Gas-Phase Photolysis and Temperature-Dependent OH Reaction Kinetics of 4-Hydroxy-2-butanone. Environ. Sci. Technol. 2015, 49 (20), 12178-12186.