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Phorbol 12-myristate 13-acetate, 95%
Activates protein kinase C and promotes skin tumors in mice | CAS: 16561-29-8 | C36H56O8 | 616.84 g/mol
| Catalog Number | Quantity |
|---|---|
| ALFJ63916.MA | 10 mg |
Catalog number ALFJ63916.MA
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Quantity:
10 mg
Specifications
Chemical Name or MaterialPhorbol 12-myristate 13-acetate
CAS16561-29-8
Health Hazard 1H315-H319-H335
Health Hazard 2GHS H Statement
H315
Causes skin irritation.
H315
Causes skin irritation.
Health Hazard 3P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
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PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
General References:
- Vicentini, L.M.; Di Virgilio, F.; Ambrosini, A.; Pozzan, T.; Meldolesi, J. Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells. Biochemical and Biophysical Research Communications. 1985, 127, (1), 310-317.
- Emerit, I.; Cerutti, P.A. Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes. Current Issue. 1982, 79, (23), 7509-7513.