Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
Doxycycline monohydrate
Doxycycline monohydrate, CAS # 17086-28-1, is the hydrated form of the tetracycline class antibiotic doxycycline. | CAS: 17086-28-1 | C22H26N2O9 | 462.455 g/mol
Have Questions?
Change view
Catalog number ALFJ63805.14
View Price:Sign InSign in to see your account pricing. Need an account? Register with us today.
Quantity:
25 g
Specifications
Chemical Name or MaterialDoxycycline monohydrate
TypeDoxycycline Monohydrate
Physical FormPowder
CAS17086-28-1
Health Hazard 1H361d
View more
Doxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Doxycycline monohydrate is a semi-synthetic tetracycline antibiotic with broad-spectrum activity
- It is a tetracycline with the 5beta-hydrogen group replaced by a hydroxy group
- Doxycycline monohydrate acts by binding the 30S ribosomal subunit and preventing polypeptide formation
- Doxycycline monohydrate may also act on the 50S ribosomal subunit, is a known inhibitor of collagenases, and has anti-inflammatory properties
Application
- Doxycycline can be used for study of cancers, infections, and antibiotic resistance in laboratory settings
- Doxycycline can be used experimentally to control TET genes and induce expression of genes of interest in vitro
RUO – Research Use Only
General References:
- Clemens DL, Duryee MJ, Sarmiento C, Chiou A, McGowan JD, Hunter CD, Schlichte SL, Tian J, Klassen LW, O'Dell JR, Thiele GM, Mikuls TR, Zimmerman MC, Anderson DR. Novel Antioxidant Properties of Doxycycline. Int J Mol Sci. 2018 Dec 17;19(12):4078. doi: 10.3390/ijms19124078. PMID: 30562944; PMCID: PMC6321135.
- Clemens DL, Duryee MJ, Sarmiento C, Chiou A, McGowan JD, Hunter CD, Schlichte SL, Tian J, Klassen LW, O'Dell JR, Thiele GM, Mikuls TR, Zimmerman MC, Anderson DR. Novel Antioxidant Properties of Doxycycline. Int J Mol Sci. 2018 Dec 17;19(12):4078. doi: 10.3390/ijms19124078. PMID: 30562944; PMCID: PMC6321135.