Bacitracin

Name: Bacitracin
SKU: ALFJ62432.14

Bacitracin, CAS # 1405-87-4, is cyclic polypeptide-based antibiotic which exhibits activity against microbes causing pneumonia, skin, and eye infections. | CAS: 1405-87-4 | C₆₆H₁₀₃N₁₇O₁₆S

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25 g

5 g

Catalog number ALFJ62432.14

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Specifications

Chemical Name or MaterialBacitracin

TypeBacitracin

Physical FormPowder

CAS1405-87-4

Health Hazard 1H317-H336-H373

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Bacitracin is a mixture of at least nine different cyclic polypeptides, originally isolated from Bacillus bacteria in 1945
Bacitracins work by binding divalent metal cations and preventing the hydrolysis of lipids into usable cell wall components

Applications

Bacitracin has been paired with nanoparticles in some laboratory studies to increase its effectivity
It is suitable for the laboratory study of bacterial resistance, infection, and cross-reactivity

RUO – Research Use Only

General References:

Tay, W.M.; Epperson, J.D.; da Silva, G.F.; Ming, L.J. 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity. J Am Chem Soc. 2010, 28, 132(16), 5652-61.
Karala, A.R.; Ruddock, L.W. Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J. 2010, 277(11), 2454-62.