Luzindole, 97%, Thermo Scientific Chemicals
Luzindole, 97%, Thermo Scientific Chemicals
Luzindole, 97%, Thermo Scientific Chemicals
Luzindole, 97%, Thermo Scientific Chemicals

Luzindole, 97%, Thermo Scientific Chemicals

A melatonin receptor antagonist
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Catalog NumberQuantity
ALFJ61915.MB25 mg
Catalog number ALFJ61915.MB
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Quantity:
25 mg
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Specifications
Chemical Name or MaterialLuzindole
CAS117946-91-5
Melting Point44°C to 46°C
ColorWhite to Brown
Recommended StorageStore at -20°C
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Luzindole significantly antagonizes melatonin-mediated antinociception, suggesting that MEL-1B-R plays a further role as a mediator of melatonin modulation of pain signaling. It is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Luzindole significantly antagonizes melatonin-mediated antinociception, suggesting that MEL-1B-R plays a further role as a mediator of melatonin modulation of pain signaling. It is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response

Solubility
Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water.

Notes
Protect from heat. Incompatible with heat and oxidizing agents. Store at 4°C.
RUO – Research Use Only

General References:

  1. C Browning; I Beresford; N Fraser, H Giles. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. British Journal of Pharmacology. 2000, 129, (5), 877-886.
  2. M L Dubocovich. Luzindole (N-0774): a novel melatonin receptor antagonist. Journal of Pharmacology and Experimental Therapeutics. 1988, 246, (3), 902-910.