Luzindole significantly antagonizes melatonin-mediated antinociception, suggesting that MEL-1B-R plays a further role as a mediator of melatonin modulation of pain signaling. It is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response
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Applications
Luzindole significantly antagonizes melatonin-mediated antinociception, suggesting that MEL-1B-R plays a further role as a mediator of melatonin modulation of pain signaling. It is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response
Solubility
Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water.
Notes
Protect from heat. Incompatible with heat and oxidizing agents. Store at 4°C.
RUO – Research Use Only
General References:
- C Browning; I Beresford; N Fraser, H Giles. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. British Journal of Pharmacology. 2000, 129, (5), 877-886.
- M L Dubocovich. Luzindole (N-0774): a novel melatonin receptor antagonist. Journal of Pharmacology and Experimental Therapeutics. 1988, 246, (3), 902-910.