Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
Cyclopiazonic acid, 98%
Inhibitor of the sarco/endoplasmic reticulum calcium pump, calcium-ATPase | CAS: 18172-33-3 | C20H20N2O3 | 336.391 g/mol
| Catalog Number | Quantity |
|---|---|
| ALFJ61594.MA | 10 mg |
Catalog number ALFJ61594.MA
View Price:Sign InSign in to see your account pricing. Need an account? Register with us today.
Quantity:
10 mg
Specifications
Chemical Name or MaterialCyclopiazonic acid
CAS18172-33-3
Health Hazard 1H300
Health Hazard 2GHS H Statement
H300-H361
Fatal if swallowed.
Suspected of damaging fertility or the unborn child.
H300-H361
Fatal if swallowed.
Suspected of damaging fertility or the unborn child.
Health Hazard 3P264b-P270-P301+P310-P330-P501c
View more
The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.
Solubility
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (∼20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Keep in a dry place. Keep away from strong oxidizing agents.
The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.
Solubility
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (∼20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Keep in a dry place. Keep away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Plenge-Tellechea et al. On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid. J.Biol.Chem. 1997, 272, (5), 2794-800.
- Soler et al. Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry. 1998, 37, (12) 4266-74.