1,4-Dithio-DL-threitol, 98%

Name: 1,4-Dithio-DL-threitol, 98%
SKU: ALFA15797.14

CAS: 3483-12-3 | C4H10O2S2 | 154.24 g/mol

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Catalog number ALFA15797.14

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Specifications

Chemical Name or Material1,4-Dithio-DL-threitol

CAS3483-12-3

Health Hazard 1H302-H315-H319-H335

Health Hazard 2GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Health Hazard 3P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

Useful for stabilizing sulfhydryl-containing enzymes1,4-Dithio-DL-threitol is used as a protective agent in preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Useful for stabilizing sulfhydryl-containing enzymes1,4-Dithio-DL-threitol is used as a protective agent in preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.

Solubility
Soluble in water, ethanol, chloroform, diethyl ether, acetone, ether and ethyl acetate.

Notes
Air sensitive and hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, reducing agents and alkalies.

RUO – Research Use Only

General References:

Protective agent for preventing oxidation of thiol groups and reagent for reduction of disulfide groups in proteins: Biochemistry, 3, 480 (1964); 11, 2939 (1972); J. Biol. Chem., 243, 716 (1968); Methods Enzymol., 25, 185 (1967); 143, 246 (1987).
Yang, H. K.; Zhang, L. M. New amphiphilic glycopolypeptide conjugate capable of self-assembly in water into reduction-sensitive micelles for triggered drug release. Mater. Sci. Eng. C 2014, 41, 36-41.
Feng, L.; Xie, A.; Hu, X.; Liu, Y.; Zhang, J.; Li, S.; Dong, W. A releasable disulfide carbonate linker for polyethyleneimine (PEI)-based gene vectors. New J. Chem. 2014, 38, (11), 5207-5214.