Pyrrolidine is used as building block in the synthesis of organic compounds. It is used to activate ketones and aldehydes toward nucleophilic addition. It is also utilized in promoting aldol condensation of ketones and aldehydes by forming enamine.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Pyrrolidine is used as building block in the synthesis of organic compounds. It is used to activate ketones and aldehydes toward nucleophilic addition. It is also utilized in promoting aldol condensation of ketones and aldehydes by forming enamine.
Solubility
Miscible with alcohol, ether, chloroform and water.
Notes
Store in cool place. Incompatible with acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide and acids.
RUO – Research Use Only
General References:
- Pohl, R.; Slavětínská, L. P.; Eng, W. S.; Keough, D. T.; Guddat, L. W.; Rejman, D. Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Org. Biomol. Chem. 2015, 13, 4693-4705.
- Redondo, J. A.; Velasco, D.; Pérez-Perrino, M.; Reinecke, H.; Gallardo, A.; Pandit, A.; Elvira, C. Synergistic effect of pendant hydroxypropyl and pyrrolidine moieties randomly distributed along polymethacrylamide backbones on in vitro DNA-transfection. Eur. J. Pharm. Biopharm. 2015, 90, 38-43.