Acetanilide is used as an intermediate in the synthesis of rubber accelerator, dyes and camphor. It is also used in the synthesis of penicillin and other pharmaceutical products. It is involved in the preparation of 4-acetamidobenzenesulfonyl chloride, which is an intermediate during the synthesis of sulfa drugs. Further, it is employed as a experimental photographic developer. In addition to this, it is used to stabilize cellulose ester varnishes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Acetanilide is used as an intermediate in the synthesis of rubber accelerator, dyes and camphor. It is also used in the synthesis of penicillin and other pharmaceutical products. It is involved in the preparation of 4-acetamidobenzenesulfonyl chloride, which is an intermediate during the synthesis of sulfa drugs. Further, it is employed as a experimental photographic developer. In addition to this, it is used to stabilize cellulose ester varnishes.
Solubility
Soluble in ethanol, diethyl ether, acetone, benzene. Slightly soluble in water.
Notes
Incompatible with strong oxidizing agents and strong bases.
RUO – Research Use Only
General References:
- Prema, D.; Sivakumar, K. Inclusion Complexation of Acetanilide into the beta-Cyclodextrin Nanocavity: A Computational Approach. Procedia Mater. Sci. 2015, 10, 467-475.
- Babkov, D. A.; Valuev-Elliston, V. T.; Paramonova, M. P.; Ozerov, A. A.; Ivanov, A. V.; Chizhov, A. O.; Khandazhinskaya, A. L.; Kochetkov, S. N.; Balzarini, J.; Daelemans, D.; Pannecouque, C.; Seley-Radtke, K. L.; Novikov, M. S. Scaffold hopping: Exploration of acetanilide-containing uracil analogues as potential NNRTIs. Bioorg. Med. Chem. 2015, 23 (5), 1069-1081.
- Fuerst, G. B.; Ley, R. T.; Paluch, A. S. Calculating the Fugacity of Pure, Low Volatile Liquids via Molecular Simulation with Application to Acetanilide, Acetaminophen, and Phenacetin. Ind. Eng. Chem. Res. 2015, 54 (36), 9027-9037.