3-Methoxybenzaldehyde, 98%

CAS: 591-31-1 | C8H8O2 | 136.15 g/mol

Catalog Number	Quantity
ALFA13962.14	25 g

Catalog number ALFA13962.14

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Specifications

Chemical Name or Material3-Methoxybenzaldehyde

CAS591-31-1

Health Hazard 1H315-H319

Health Hazard 2GHS H Statement
H315-H319
Causes skin irritation.
Causes serious eye irritation.

Health Hazard 3P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362

3-Methoxybenzaldehyde is used to prepare 3-(3-methoxy-phenyl)-1-phenyl-propenone by reaction with benzldehyde. It is used as an eluent for mono-¹³C isotopomers of vanillin in normal phase silica gel chromatography. It acts as an inhibitor of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Methoxybenzaldehyde is used to prepare 3-(3-methoxy-phenyl)-1-phenyl-propenone by reaction with benzldehyde. It is used as an eluent for mono-¹³C isotopomers of vanillin in normal phase silica gel chromatography. It acts as an inhibitor of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.

Solubility
Slightly soluble in water. Soluble in glacial acetic acid, alcohol, chloroform, ether, carbon disulfide, methanol, aqueous solutions of alkali hydroxides.

Notes
Air sensitive. Incompatible with strong bases, strong oxidizing agents and strong reducing agents.

RUO – Research Use Only

General References:

Lithiation and methylation normally gives a mixture of 2-, 4- and 6-methyl derivatives. Systematic study has found that using PhLi and trimethylethylenediamine increases the degree of 2-lithiation to 96%: J. Org. Chem., 54, 3730 (1989).
Bhowmick, D.; Srivastava, S.; D’Silva, P.; Mugesh, G. Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage. Angew. Chem. 2015, 127 (29), 8569-8573.
Marri, G.; Reddy, J. S.; Ruiz, J.; Das, S.; Gree, R. Stereoselective TiCl₄-Mediated Aldol Reactions Starting from Acylsilanes. Eur. J. Org. Chem. 2015, 2015 (4), 840-846.