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1-Phenyl-3-pyrazolidinone, 97%
CAS: 92-43-3 | C9H10N2O | 162.192 g/mol
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Catalog number ALFA12089.30
Price (MYR)
970.00
EA
Quantity:
250 g
Price (MYR)
970.00
EA
Specifications
Chemical Name or Material1-Phenyl-3-pyrazolidinone
CAS92-43-3
Health Hazard 1H301
Health Hazard 2GHS H Statement
H302
Harmful if swallowed.
H302
Harmful if swallowed.
Health Hazard 3P264b-P270-P301+P310-P330-P501c
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Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Solubility
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol.
Notes
Store in cool place. Keep away from oxidizing agents.
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Solubility
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol.
Notes
Store in cool place. Keep away from oxidizing agents.
RUO – Research Use Only
General References:
- Dennis J. Hlasta.; Francis B. Casey.; Edward W. Ferguson.; Sally J. Gangell.; Martha R. Heimann.; Edward P. Jaeger.; Rudolph K. Kullnig.; Robert J. Gordon. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J. Med. Chem. 1991, 34 (5),1560-1570.
- Hong-Jun Wang.; Jeffrey Keilman.; Chittari Pabba.; Zhen-Jia Chen.; Brian T. Gregg. Microwave-assisted cross-coupling of 3-chloro-2-pyrazolines and 3-chloro-1-phenyl-1,4,5,6-tetrahydropyridazine with aryl boronic acids. Tetrahedron Lett. 2005, 46 (15),2631-2634.