Pyridine-4-carboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.
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Applications
Pyridine-4-carboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.
Solubility
Soluble in water (20 mg/ml at 20°C), ethanol and acetone.
Notes
It is air and light sensitive. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Nand K.Singh; Rajesh Tripathi. Synthesis and structural characterization of 3d-metal complexes of pyridine-4-carboxaldehyde thionicotinoyl hydrazone. Transition Metal Chemistry. 1988, 13, (5),346-350
- A.Martin; B.Lucke; H.J.Niclas; A.Forster. Vapor-phase oxidation of 4-picoline to pyridine-4-carboxaldehyde on a vanadium phosphate catalysts. Reaction Kinetics and Catalysis Letters. 1991, 43, (2),583-588
- In the presence of DBU, converts amines to carbonyl compounds, e.g. benzylamines to benzaldehydes: Synthesis, 756 (1982):
- The reaction is also useful for the conversion of ɑ-amino acids to ɑ-keto acids.